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CHM 2101

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Drug Profile

CHM 2101

Alternative Names: Cadherin 17 chimeric antigen receptor-positive (CAR) T cells; Cadherin-17; CDH17-CAR T; CHM-2101; CHM-2101 CAR-T cells

Latest Information Update: 28 Dec 2025

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At a glance

  • Originator University of Pennsylvania
  • Developer Chimeric Therapeutics; University of Pennsylvania
  • Class Antineoplastics; Antineoplastons; CAR-T cell therapies; Gene therapies; Immunotherapies
  • Mechanism of Action Immunologic cytotoxicity; T lymphocyte replacements
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity No
  • Available For Licensing Yes

Highest Development Phases

  • Phase I/II Colorectal cancer; Gastric cancer; Neuroendocrine tumours
  • Preclinical Solid tumours
  • No development reported Pancreatic cancer

Most Recent Events

  • 28 Dec 2025 No recent reports of development identified for preclinical development in Pancreatic-cancer in USA (Parenteral)
  • 31 May 2024 Phase-I/II clinical trials in Colorectal cancer (Late-stage disease, Metastatic disease, Second-line therapy or greater) in USA (Parenteral) (NCT06055439)
  • 31 May 2024 Phase-I/II clinical trials in Gastric cancer (Late-stage disease, Metastatic disease, Second-line therapy or greater) in USA (Parenteral) (NCT06055439)

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