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STX 478

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Drug Profile

STX 478

Alternative Names: LY-4064809; ST-814; STX-478; STX-H1047-PI3Ka inhibitors - Scorpion Therapeutics

Latest Information Update: 23 Sep 2025

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At a glance

  • Originator Scorpion Therapeutics
  • Class Antineoplastics; Small molecules
  • Mechanism of Action Phosphatidylinositol 3 kinase alpha inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase I/II Solid tumours

Most Recent Events

  • 20 May 2025 Eli Lilly and Company initiates enrolment in the phase I (In volunteers) trial in the US (NCT06991179)
  • 06 May 2025 Eli Lilly and Company completes the phase I trial (In volunteers) in the US (NCT06901336)
  • 25 Apr 2025 Pharmacodynamics data from preclinical trial in Colorectal cancer (CRC) presented at the 116th Annual Meeting of the American Association for Cancer Research (AACR-2025)

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