STX 478
Alternative Names: LY-4064809; ST-814; STX-478; STX-H1047-PI3Ka inhibitors - Scorpion TherapeuticsLatest Information Update: 25 Nov 2025
At a glance
- Originator Scorpion Therapeutics
- Developer Eli Lilly and Company; Scorpion Therapeutics
- Class Antineoplastics; Small molecules
- Mechanism of Action Phosphatidylinositol 3 kinase alpha inhibitors
-
Orphan Drug Status
No
Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.
- New Molecular Entity Yes
Highest Development Phases
- Phase III Breast cancer
- Phase I/II Solid tumours
Most Recent Events
- 27 Oct 2025 Phase-III clinical trials in Breast cancer (Combination therapy, Metastatic disease, First-line therapy) in USA (PO) (NCT07174336)
- 24 Oct 2025 Phase-I clinical trials in Solid tumours (In volunteers) in Singapore (PO) (NCT07247357)
- 20 May 2025 Eli Lilly and Company initiates enrolment in the phase I (In volunteers) trial in the US (NCT06991179)