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RG 6440

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Drug Profile

RG 6440

Alternative Names: RG-6440; RO-7496353; SOF-10

Latest Information Update: 29 Aug 2025

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At a glance

  • Originator Chugai Pharmaceutical
  • Developer Chugai Pharmaceutical; Genentech; Roche
  • Class Antineoplastics; Immunotherapies; Monoclonal antibodies
  • Mechanism of Action Antibody-dependent cell cytotoxicity; Immunostimulants; Transforming growth factor beta1 inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Discontinued Solid tumours

Most Recent Events

  • 30 Jun 2025 Discontinued - Phase-I for Solid tumours (Combination therapy, In the elderly, Late-stage disease, Metastatic disease, Recurrent, In adults) in Japan (IV) (Chugai Pharmaceuticals pipeline, August 2025)
  • 30 Jun 2025 Discontinued - Phase-I for Solid tumours (Combination therapy, Late-stage disease, Recurrent, Second-line therapy or greater) in Japan (IV) (Chugai Pharmaceuticals pipeline, August 2025)
  • 30 Jun 2025 Discontinued - Phase-I for Solid tumours in USA (IV) (Chugai Pharmaceuticals pipeline, August 2025)

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