Either you have JavaScript disabled or your browser does not support Javascript . To work properly, this page requires JavaScript to be enabled.
How to enable JavaScript in your browser?

TOS 358

Next Previous
X
Search
Drug Profile

TOS 358

Alternative Names: TOS-358

Latest Information Update: 12 Apr 2023

Price :

$50 *

Note:
  • Adis is an information provider. We do not sell or distribute actual drugs.
  • Final gross price and currency may vary according to local VAT and billing address.
  • Your purchase entitles you to full access to the information contained in our drug profile at the time of purchase.
  • A link to download a PDF version of the drug profile will be included in your email receipt.

At a glance

  • Originator Totus Medicines
  • Class Antineoplastics; Small molecules
  • Mechanism of Action Phosphatidylinositol 3 kinase alpha inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase I Solid tumours
  • Research Cancer; CNS cancer; Colorectal cancer; Haematological malignancies; Lung cancer

Most Recent Events

  • 10 Apr 2023 US FDA approves IND application for TOS 358 in Solid tumours, before February 2023
  • 15 Feb 2023 Phase-I clinical trials in Solid tumours (Metastatic disease, Late-stage disease, Recurrent, Second-line therapy or greater) in USA (PO) (NCT05683418)
  • 23 Feb 2022 Early research in Lung cancer, CNS cancer, Cancer (RAS mutant, Oncogenic mutant multiple cancers), Hematological malignancies and Colorectal cancer in USA (unspecified route) as of February 2022 (Totus Medicines pipeline; February 2022)

You need to be a logged in or subscribed to view this content Request demo

If your organization or you do not have a subscription, try one of the following:
  • Contacting your organization’s admin about adding this content to your AdisInsight subscription
  • Buying a PDF version of any individual profile
  • Request a free trial
If your organization has a subscription, there are several access options, even while working remotely:
  • Working within your organization’s network
  • with username/password or try to via your institution
  • Persisted access using your organization’s identifier stored in your user browser for 90 days
Back to top