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TOS 358

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Drug Profile

TOS 358

Alternative Names: TOS-358

Latest Information Update: 28 May 2026

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At a glance

  • Originator Totus Medicines
  • Class Antineoplastics; Small molecules
  • Mechanism of Action Phosphatidylinositol 3 kinase alpha inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • No development reported Cancer; CNS cancer; Colorectal cancer; Haematological malignancies; HER2 negative breast cancer; Lung cancer

Most Recent Events

  • 28 May 2026 No recent reports of development identified for phase-I development in HER2-negative-breast-cancer(Combination therapy, Late-stage disease, Metastatic disease, Recurrent, Second-line therapy or greater) in Spain (PO)
  • 28 May 2026 No recent reports of development identified for phase-I development in HER2-negative-breast-cancer(Combination therapy, Late-stage disease, Metastatic disease, Recurrent, Second-line therapy or greater) in USA (PO)
  • 06 May 2026 Updated efficacy and safety data from the doublet cohort of a phase I/Ib trial in HER2-negative-breast-cancer released by Totus Medicines

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