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Aflibercept biosimilar - Alvotech

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Drug Profile

Aflibercept biosimilar - Alvotech

Alternative Names: Afiveg; AVT-06; AVT-29; Mynzepli; Vgenfli

Latest Information Update: 24 Sep 2025

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At a glance

  • Originator Alvotech
  • Developer Alvotech; Teva Pharmaceutical Industries
  • Class Antineoplastics; Eye disorder therapies; Immunoglobulin Fc fragments; Immunoglobulin fragments; Recombinant fusion proteins
  • Mechanism of Action Placenta growth factor inhibitors; Vascular endothelial growth factor A inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity No
  • Available For Licensing Yes

Highest Development Phases

  • Registered Retinal disorders; Wet age-related macular degeneration

Most Recent Events

  • 19 Sep 2025 Registered for Wet age-related macular degeneration (Treatment-naive) in Japan (Intravitreous)
  • 19 Sep 2025 Japanese Ministry of Health, Labor and Welfare recommends approval of AVT 06 for Rheumatoid arthritis in Japan
  • 21 Aug 2025 Registered for Retinal disorders in Europe (Intravitreous)

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