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NC 525

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Drug Profile

NC 525

Alternative Names: LAIR-1 mAb - NextCure; NC-525

Latest Information Update: 08 Oct 2025

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At a glance

  • Originator NextCure
  • Class Antineoplastics; Immunotherapies; Monoclonal antibodies
  • Mechanism of Action Antibody-dependent cell cytotoxicity; Cell death stimulants; Leukocyte-associated immunoglobulin-like receptor 1 antagonists; T lymphocyte stimulants
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes
  • Available For Licensing Yes

Highest Development Phases

  • Discontinued Acute myeloid leukaemia; Chronic myelomonocytic leukaemia; Myelodysplastic syndromes

Most Recent Events

  • 08 Oct 2025 Discontinued - Phase-I for Acute myeloid leukaemia (Late-stage disease, Second-line therapy or greater) in USA (IV) (NextCure pipeline; October 2025)
  • 08 Oct 2025 Discontinued - Phase-I for Chronic myelomonocytic leukaemia (Late-stage disease, Second-line therapy or greater) in USA (IV) (NextCure pipeline; October 2025)
  • 08 Oct 2025 Discontinued - Phase-I for Myelodysplastic syndromes (Late-stage disease, Second-line therapy or greater) in USA (IV) (NextCure pipeline; October 2025)

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