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Precemtabart tocentecan - Merck KGaA

Drug Profile

Precemtabart tocentecan - Merck KGaA

Alternative Names: M-9140

Latest Information Update: 29 Apr 2026

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At a glance

  • Originator Merck KGaA
  • Developer EMD Serono Research & Development Institute; Merck KGaA
  • Class Alkaloids; Antibodies; Antineoplastics; Camptothecins; Drug conjugates; Immunoconjugates
  • Mechanism of Action DNA topoisomerase I inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes
  • Available For Licensing Yes

Highest Development Phases

  • Phase I/II Solid tumours
  • Phase I Colorectal cancer

Most Recent Events

  • 24 Apr 2026 EMD Serono Research & Development Institute with Merck KGaA plans to initiate a phase III PROCEADE-CRC-03 trial for Colorectal cancer (Metastatic disease, Monotherapy, Combination therapy, Second-line therapy) in the US and Germany (IV) in May 2026 (NCT07549412)
  • 31 Mar 2026 Phase-I/II clinical trials in Solid tumours (Late-stage disease, Metastatic disease, Monotherapy) in China, Germany, Italy, Spain (IV) (NCT06710132)
  • 04 Mar 2026 Merck KGaA plans a phase-III trial for Colorectal cancer (Metastatic disease) in 2026 (Parenteral)

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