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ASP 8731

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Drug Profile

ASP 8731

Alternative Names: ASP-8731; ML-0207

Latest Information Update: 09 May 2023

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At a glance

  • Originator Mitobridge
  • Developer Astellas Pharma; Mitobridge
  • Class Antianaemics; Small molecules
  • Mechanism of Action BACH1 protein inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Sickle cell anaemia
  • New Molecular Entity Yes

Highest Development Phases

  • Discontinued Sickle cell anaemia

Most Recent Events

  • 30 Apr 2023 Discontinued - Phase-I for Sickle cell anaemia (In volunteers, In adults) in USA (PO)
  • 01 Mar 2023 Astellas Pharma terminates phase I trial in Sickle cell anaemia (In volunteers, In adults) in USA (PO) so as protocol defined stopping criteria meets (NCT05167526)
  • 01 Sep 2022 ASP 8731 receives Orphan Drug status for Sickle cell anaemia in USA

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