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KT 253

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Drug Profile

KT 253

Alternative Names: KT-253

Latest Information Update: 06 Jun 2024

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At a glance

  • Originator Kymera Therapeutics
  • Class Antineoplastics; Small molecules
  • Mechanism of Action Apoptosis stimulants; Proto-oncogene protein c-mdm2 degraders
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Acute myeloid leukaemia
  • New Molecular Entity Yes

Highest Development Phases

  • Phase I Acute myeloid leukaemia; Lymphoma; Myelodysplastic syndromes; Myeloproliferative disorders; Precursor cell lymphoblastic leukaemia-lymphoma; Solid tumours
  • Preclinical Haematological malignancies; Merkel cell carcinoma

Most Recent Events

  • 03 Jun 2024 Efficacy and adverse events data from a phase I trial in haematological malignancies and solid tumours released by Kymera Therapeutics
  • 23 May 2024 Updated pharmacodynamic, efficacy, and adverse event data from a phase I trial in Haematological malignancies and Solid tumours presented at the 60th Annual Meeting of the American Society of Clinical Oncology (ASCO-2024)
  • 02 Nov 2023 Pharmacokinetic, efficacy, and adverse event data from a phase I trial in Haematological malignancies and Solid tumours released by Kymera Therapeutics

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