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KT 253

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Drug Profile

KT 253

Alternative Names: KT-253

Latest Information Update: 04 Feb 2025

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At a glance

  • Originator Kymera Therapeutics
  • Class Antineoplastics; Small molecules
  • Mechanism of Action Apoptosis stimulants; Proto-oncogene protein c-mdm2 degraders
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Acute myeloid leukaemia
  • New Molecular Entity Yes

Highest Development Phases

  • Phase I Acute myeloid leukaemia; Lymphoma; Myelodysplastic syndromes; Myeloproliferative disorders; Precursor cell lymphoblastic leukaemia-lymphoma; Solid tumours
  • Preclinical Haematological malignancies; Merkel cell carcinoma

Most Recent Events

  • 04 Feb 2025 Kymera Therapeutics completes a Phase-I clinical trials in Myelodysplastic syndromes, Myeloproliferative disorders, Acute myeloid leukaemia, Lymphoma, Precursor cell lymphoblastic leukaemia-lymphoma, Solid tumours (Late-stage disease, Second-line therapy or greater) in USA (IV) (NCT05775406)
  • 07 Dec 2024 Pharmacodynamics data from a preclinical trial in Myeloproliferative disorders presented at the 66th American Society of Hematology Annual Meeting and Exposition (ASH-Hem-2024)
  • 03 Jun 2024 Efficacy and adverse events data from a phase I trial in haematological malignancies and solid tumours released by Kymera Therapeutics

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