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SENT 001

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Drug Profile

SENT 001

Alternative Names: AVB-001; SENT-001

Latest Information Update: 23 Sep 2025

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At a glance

  • Originator Avenge Bio
  • Class Antineoplastics; Cell therapies; Gene therapies; Immunotherapies; Interleukins
  • Mechanism of Action Cell replacements; Interleukin 2 replacements
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Mesothelioma
  • New Molecular Entity No

Highest Development Phases

  • Phase I/II Fallopian tube cancer; Ovarian cancer; Peritoneal cancer
  • Discontinued Colorectal cancer; Lung cancer; Mesothelioma

Most Recent Events

  • 30 May 2025 Efficacy, pharmacodynamics and adverse events data from a phase I trial in Ovarian cancer, Fallopian tube cancer, and Peritoneal cancer presented at the 61st Annual Meeting of the American Society of Clinical Oncology (ASCO-2025)
  • 29 May 2025 SENT 001 is still in a phase-I/II trial in Ovarian cancer, Fallopian tube cancer, Peritoneal cancer (Inoperable/Unresectable, Metastatic disease, Second-line therapy or greater) in USA (Intraperitoneal)(NCT05538624)
  • 29 May 2025 Sentinel BioTherapeutics plans clinical trials for Solid tumors

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