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TN 401

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Drug Profile

TN 401

Alternative Names: TN-401

Latest Information Update: 18 Dec 2025

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At a glance

  • Originator Tenaya Therapeutics
  • Class Cardiovascular therapies; Gene therapies
  • Mechanism of Action Gene transference; Plakophilin 2 replacements
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Arrhythmogenic right ventricular dysplasia
  • New Molecular Entity No

Highest Development Phases

  • Phase I/II Arrhythmogenic right ventricular dysplasia

Most Recent Events

  • 12 Dec 2025 Efficacy, adverse events and pharmacodynamics data from the phase Ib/II RIDGE-1 trial in Arrhythmogenic right ventricular dysplasia released by Tenaya Therapeutics
  • 25 Nov 2024 Phase-I/II clinical trials in Arrhythmogenic right ventricular dysplasia in United Kingdom (IV) (NCT06228924)
  • 01 Oct 2024 Tenaya Therapeutics has patent protection for method of treating an arrhythmogenic right ventricular cardiomyopathy (ARVC) with an AAV9 virion encoding the PKP2 protein in USA

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