Drug Profile

TN 401

Alternative Names: TN-401

Latest Information Update: 27 Mar 2026

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At a glance

Originator Tenaya Therapeutics
Class Cardiovascular therapies; Gene therapies
Mechanism of Action Gene transference; Plakophilin 2 replacements

Orphan Drug Status

Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

Yes - Arrhythmogenic right ventricular dysplasia
New Molecular Entity No

Highest Development Phases

Phase I/II Arrhythmogenic right ventricular dysplasia

Most Recent Events

12 Mar 2026 Tenaya Therapeutics has protection for TN 401
09 Jan 2026 Tenaya Therapeutics plans to pursue regulatory alignment on TN 401 pivotal studies in the second half of 2026
12 Dec 2025 Efficacy, adverse events and pharmacodynamics data from the phase Ib/II RIDGE-1 trial in Arrhythmogenic right ventricular dysplasia released by Tenaya Therapeutics

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