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Purified exosome product - RION

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Drug Profile

Purified exosome product - RION

Alternative Names: 10% PEP; 20% PEP; PEP; PEP Biologic™; PEPTM; Purified Exosome ProductTM

Latest Information Update: 06 Jul 2026

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At a glance

  • Originator Mayo Foundation for Medical Education and Research
  • Developer Mayo Foundation for Medical Education and Research; RION
  • Class Blood products and substitutes; Exosome therapies
  • Mechanism of Action Angiogenesis inducing agents; Exosome replacements
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity No
  • Available For Licensing Yes

Highest Development Phases

  • Phase II Diabetic foot ulcer
  • Phase I Osteoarthritis
  • No development reported Alopecia; Joint disorders; Urinary incontinence; Wounds
  • Discontinued Crohn's disease

Most Recent Events

  • 01 Jul 2026 Purified exosome product - RION receives Breakthrough Therapy status for Diabetic foot ulcer in USA
  • 01 Jul 2026 INTENT Biologics plans a phase III trial for Diabetic foot ulcer
  • 28 Mar 2026 No recent reports of development identified for preclinical development in Alopecia in USA (Parenteral, Injection)

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