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CDI 988

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Drug Profile

CDI 988

Alternative Names: CDI-988

Latest Information Update: 30 Dec 2025

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At a glance

  • Originator Cocrystal Pharma Inc
  • Class Antivirals; Small molecules
  • Mechanism of Action 3C viral protease inhibitors; Coronavirus 3C-like proteinase inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase I COVID 2019 infections; Norovirus infections

Most Recent Events

  • 18 Dec 2025 Cocrystal Pharma receives approval from the Institutional Review Board (IRB) to initiate a phase Ib human challenge study with CDI 988
  • 14 Nov 2025 Cocrystal Pharma plans a phase Ib/II human challenge study for Norovirus infections (In Volunteers) in USA in the first quarter 2026 (PO) (NCT07198139)
  • 12 Sep 2025 US FDA approves IND application for CDI 988 for prevention and treatment of Norovirus infection, prior to September 2025

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