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RG 6333

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Drug Profile

RG 6333

Alternative Names: CD19 X CD28 - Roche; RG-6333; RO-7443904

Latest Information Update: 16 Aug 2024

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At a glance

  • Originator Roche
  • Class Antineoplastics; Bispecific antibodies; Immunotherapies
  • Mechanism of Action CD19 antigen modulators; CD28 antigen modulators; Cytotoxic T lymphocyte stimulants
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Discontinued Non-Hodgkin's lymphoma

Most Recent Events

  • 16 Aug 2024 Discontinued - Phase-I for Non-Hodgkin's lymphoma (Combination therapy, Metastatic disease, Second-line therapy or greater) in Australia, USA, Denmark, France, Italy, United Kingdom (SC) (Roche pipeline, August 2024)
  • 16 Aug 2024 Discontinued - Phase-I for Non-Hodgkin's lymphoma (Combination therapy, Metastatic disease, Second-line therapy or greater) in United Kingdom, Italy, France, Denmark, USA, Australia (IV) (Roche pipeline, August 2024)
  • 17 Jul 2024 Roche terminates a phase I clinical trials in Non-Hodgkin's lymphoma (Combination therapy, Metastatic disease, Second-line therapy or greater) in United Kingdom, Italy, France, Denmark, USA (SC) due to sponsor portfolio re-alignment (NCT05219513)

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