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Spevatamig - Phanes Therapeutics

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Drug Profile

Spevatamig - Phanes Therapeutics

Alternative Names: Anti-claudin18.2/anti-CD47 bispecific antibody; PT-886

Latest Information Update: 16 Oct 2026

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At a glance

  • Originator Phanes Therapeutics
  • Class Antineoplastics; Bispecific antibodies; Immunotherapies
  • Mechanism of Action Antibody-dependent cell cytotoxicity; CD47 antigen inhibitors; Macrophage stimulants
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Pancreatic cancer
  • New Molecular Entity Yes
  • Available For Licensing Yes

Highest Development Phases

  • Phase II Gastric cancer; Oesophageal cancer; Pancreatic cancer
  • Phase I/II Adenocarcinoma; Biliary cancer; Colorectal cancer

Most Recent Events

  • 14 Oct 2026 Phase-I/II clinical trials in Colorectal cancer (Combination therapy, Metastatic disease, Late-stage disease, Second-line therapy or greater, Inoperable/Unresectable) in USA (IV) (NCT05482893)
  • 14 Oct 2026 Phase-I/II clinical trials in Colorectal cancer (Monotherapy, Second-line therapy or greater, Late-stage disease, Metastatic disease, Inoperable/Unresectable) in USA (IV) (NCT05482893)
  • 16 Sep 2026 Phanes Therapeutics has patent protection for antibody technology platform (PACbody®) in USA

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