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Spevatamig - Phanes Therapeutics

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Drug Profile

Spevatamig - Phanes Therapeutics

Alternative Names: Anti-claudin18.2/anti-CD47 bispecific antibody; PT-886

Latest Information Update: 28 Mar 2026

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At a glance

  • Originator Phanes Therapeutics
  • Class Antineoplastics; Bispecific antibodies; Immunotherapies
  • Mechanism of Action Antibody-dependent cell cytotoxicity; CD47 antigen inhibitors; Macrophage stimulants
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Pancreatic cancer
  • New Molecular Entity Yes
  • Available For Licensing Yes

Highest Development Phases

  • Phase II Gastric cancer; Oesophageal cancer; Pancreatic cancer
  • Phase I/II Biliary cancer

Most Recent Events

  • 28 Mar 2026 No recent reports of development identified for preclinical development in Pancreatic-cancer in USA (IV, Infusion)
  • 09 Jan 2026 Efficacy and adverse events data from phase I/II trial in Adenocarcinoma released by Phanes Therapeutics (Parenteral)
  • 04 Nov 2025 Spevatamig is still in phase I/II trials for Pancreatic cancer in the US (NCT05482893)

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