Drug Profile

AG 181

Alternative Names: AG-181; PAH - Agios Pharmaceuticals

Latest Information Update: 26 Nov 2025

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At a glance

Originator Agios Pharmaceuticals
Class Small molecules
Mechanism of Action Phenylalanine hydroxylase modulators

Orphan Drug Status

Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

No
New Molecular Entity Yes
Available For Licensing Yes

Highest Development Phases

Phase I Phenylketonuria

Most Recent Events

21 Nov 2025 Agios Pharmaceuticals plans a phase I trial for Phenylketonuria (PO) in March 2026 (NCT07241234) (CTIS2025-522630-31-00)
01 Feb 2025 AGIOS Pharmaceutical has patent protection for AG-181 in USA
31 Dec 2024 AGIOS Phamaceuticals issues patents and pending patent applications in Argentina, Australia, Brazil, Canada, China, Europe, Japan, Lebanon, Mexico, Eurasia, Saudi Arabia, and Taiwan

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