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KRM II 81

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Drug Profile

KRM II 81

Alternative Names: KRM-II-81

Latest Information Update: 27 Nov 2025

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At a glance

  • Originator University of Wisconsin at Milwaukee
  • Developer RespireRx Pharmaceuticals; University of Wisconsin at Milwaukee
  • Class Analgesics; Antiepileptic drugs; Anxiolytics; Small molecules
  • Mechanism of Action GABA A receptor modulators
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Preclinical Epilepsy; Pain

Most Recent Events

  • 19 Nov 2025 The UWM Research Foundation (UWMRF) and RespireRx Pharmaceuticals have amended and restated their patent license agreement
  • 23 Sep 2025 RespireRx Pharmaceuticals receives SBIR grant from National Institutes of Health (NIH) and National Institute of Neurological Disorders and Stroke (NINDS) for KRM II 81 development in epilepsy on September 2025
  • 05 Dec 2022 RespireRx Pharmaceuticals enters a collaboration with National Institute of Neurological Disorders and Stroke to develop KRM II 81 in Pain

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