Drug Profile

Blixeprodil - Gilgamesh Pharmaceuticals

Alternative Names: GM-1020

Latest Information Update: 12 Jan 2026

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At a glance

Originator Gilgamesh Pharmaceuticals
Class Antidepressants; Small molecules
Mechanism of Action NMDA receptor antagonists

Orphan Drug Status

Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

No
New Molecular Entity Yes

Highest Development Phases

Phase II Major depressive disorder

Most Recent Events

06 Jan 2026 Topline efficacy and adverse event data from a phase IIa trial in Major depressive disorder released by Gilgamesh Pharmaceuticals
01 May 2024 Gilgamesh Pharmaceuticals has patent protection for blixeprodil in USA
01 Feb 2024 Phase-II clinical trials in Major depressive disorders in United Kingdom (PO) (NCT06309277)

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