Drug Profile

Bretisilocin - AbbVie/Gilgamesh Pharmaceuticals

Alternative Names: GM-2505

Latest Information Update: 05 Apr 2026

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At a glance

Originator Gilgamesh Pharmaceuticals
Class Antidepressants; Diethylamines; Fluorinated hydrocarbons; Indoles; Methylamines; Small molecules
Mechanism of Action Serotonin 5-HT2A receptor agonists

Orphan Drug Status

Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

No
New Molecular Entity Yes

Highest Development Phases

Phase II Major depressive disorder
Phase I Depressive disorders

Most Recent Events

05 Apr 2026 Chemical structure information added.
17 Oct 2025 AbbVie completes acquisition of Gilgamesh Pharmaceuticals' Bretisilocin
25 Aug 2025 AbbVie and Gilgamesh Pharmaceuticals enters into a definitive agreement to acquire Bretisilocin

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