Drug Profile

Bretisilocin - AbbVie/Gilgamesh Pharmaceuticals

Alternative Names: GM-2505

Latest Information Update: 02 Sep 2025

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At a glance

Originator Gilgamesh Pharmaceuticals
Class Antidepressants; Small molecules
Mechanism of Action Serotonin 5-HT2A receptor agonists

Orphan Drug Status

Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

No
New Molecular Entity Yes

Highest Development Phases

Phase II Major depressive disorder
Phase I Depressive disorders

Most Recent Events

25 Aug 2025 AbbVie and Gilgamesh Pharmaceuticals enters into a definitive agreement to acquire Bretisilocin
27 May 2025 Efficacy and adverse event data from a phase IIa trial in Major depressive disorder released by Gilgamesh Pharmaceuticals
30 Nov 2023 Gilgamesh Pharmaceuticals plans a phase IIa trial for major depressive disorder in Q1 of 2024

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