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Bretisilocin - AbbVie/Gilgamesh Pharmaceuticals

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Drug Profile

Bretisilocin - AbbVie/Gilgamesh Pharmaceuticals

Alternative Names: GM-2505

Latest Information Update: 10 Jul 2026

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At a glance

  • Originator Gilgamesh Pharmaceuticals
  • Class Antidepressants; Diethylamines; Fluorinated hydrocarbons; Indoles; Methylamines; Small molecules
  • Mechanism of Action Serotonin 5-HT2A receptor agonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Major depressive disorder
  • No development reported Depressive disorders

Most Recent Events

  • 26 May 2026 AbbVie initiates a phase I pharmacokinetics trial (In volunteers) in USA (IM, Injection) (NCT07604558)
  • 26 May 2026 AbbVie plans a phase I trial (In volunteers), in May 2026 (IM, Injection) (NCT07604558)
  • 28 Apr 2026 No recent reports of development identified for phase-I development in Depressive disorders in USA

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