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ABBV 453

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Drug Profile

ABBV 453

Alternative Names: ABBV-453

Latest Information Update: 26 Aug 2025

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At a glance

  • Originator AbbVie
  • Class Antineoplastics; Small molecules
  • Mechanism of Action Proto-oncogene protein c-bcl-2 inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase I/II Multiple myeloma
  • Phase I Chronic lymphocytic leukaemia

Most Recent Events

  • 23 Jul 2025 Phase-I/II clinical trials in Multiple myeloma (Second-line therapy or greater, Combination therapy) in Japan, Israel, USA (PO) (NCT06953960)
  • 23 Jul 2025 Phase-I/II clinical trials in Multiple myeloma (Second-line therapy or greater, Monotherapy) in Japan, Israel, USA (PO) (NCT06953960)
  • 28 Jun 2025 No recent reports of development identified for phase-I development in Multiple-myeloma(Second-line therapy or greater) in Australia (PO, Tablet)

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