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ABBV 453

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Drug Profile

ABBV 453

Alternative Names: ABBV-453

Latest Information Update: 08 May 2025

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At a glance

  • Originator AbbVie
  • Class Antineoplastics; Small molecules
  • Mechanism of Action Proto-oncogene protein c-bcl-2 inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase I Chronic lymphocytic leukaemia; Multiple myeloma

Most Recent Events

  • 01 May 2025 AbbVie plans a phaseI/II trial for Multiple Myeloma (Monotherapy, Combination-therapy, Second-line therapy or greater) (PO, Tablet), in June 2025 (NCT06953960)
  • 27 Jan 2025 Phase-I clinical trials in Chronic lymphocytic leukaemia (Combination therapy, Second-line therapy or greater) in Italy, Germany, Australia (PO) (NCT06291220)
  • 07 Dec 2024 Pharmacodynamics data from a preclinical trial in lymphocytic leukaemia presented at the 66th American Society of Hematology Annual Meeting and Exposition (ASH-2024)

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