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JS 105

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Drug Profile

JS 105

Alternative Names: JS-105; RP-903

Latest Information Update: 12 Jan 2026

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At a glance

  • Originator Risen Pharma
  • Developer Risen Pharma; Shanghai Junshi Biosciences
  • Class Antineoplastics; Small molecules
  • Mechanism of Action Phosphatidylinositol 3 kinase alpha inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase III Breast cancer
  • Phase II/III Solid tumours
  • Phase I Congenital abnormalities

Most Recent Events

  • 12 Nov 2025 Phase-III clinical trials in Breast cancer (Combination therapy, Inoperable/Unresectable, Metastatic disease, Recurrent) in China (PO) (NCT07207070)
  • 17 Oct 2025 Efficacy and adverse events data from a phase I trial in Solid tumours presented at the 50th European Society for Medical Oncology Congress (ESMO-2025)
  • 17 Oct 2025 Efficacy and adverse events data from a phase I/II trial in Solid tumours presented at the 50th European Society for Medical Oncology Congress (ESMO-2025)

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