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JS 105

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Drug Profile

JS 105

Alternative Names: JS-105; RP-903

Latest Information Update: 18 Aug 2025

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At a glance

  • Originator Risen Pharma
  • Developer Risen Pharma; Shanghai Junshi Biosciences
  • Class Antineoplastics; Small molecules
  • Mechanism of Action Phosphatidylinositol 3 kinase alpha inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II/III Solid tumours
  • Phase I Breast cancer; Congenital abnormalities

Most Recent Events

  • 18 Aug 2025 Phase-I clinical trials in Congenital-abnormalities in China (PO), prior to August 2025 (Risen Pharma pipeline, August 2025)
  • 18 Aug 2025 Phase-II/III clinical trials in Solid tumours (Late-stage disease) in China (PO), prior to August 2025 (Risen Pharma pipeline, August 2025)
  • 18 Aug 2025 Phase-II/III clinical trials in Solid tumours (Late-stage disease) in USA (PO), prior to August 2025 (Risen Pharma pipeline, August 2025)

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