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KNS 366

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Drug Profile

KNS 366

Alternative Names: KMO inhibitor - Kynos Therapeutics; KNS-366; Kynurenine 3-monooxygenase inhibitor - Kynos Therapeutics

Latest Information Update: 06 Oct 2025

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At a glance

  • Originator GlaxoSmithKline; University of Edinburgh
  • Developer Kynos Therapeutics
  • Class Anti-inflammatories; Benzoxazines; Benzoxazoles; Chlorine compounds
  • Mechanism of Action Kynurenine 3-monooxygenase inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase I Inflammation
  • Preclinical Metabolic disorders

Most Recent Events

  • 06 Oct 2025 Phase-I development is ongoing in Inflammation (In volunteers) in United Kingdom (IV) (ISRCTN10496020)
  • 22 Apr 2024 Pharmacodynamics and Adverse events data from a phase I trial in Inflammation released by Kynos Therapeutics
  • 23 Jan 2024 Kynos Therapeutics completes a phase I trial in Inflammation (In volunteers) in United Kingdom (IV) (ISRCTN10496020)

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