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IDE 705

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Drug Profile

IDE 705

Alternative Names: DNA polymerase theta helicase inhibitor - IDEAYA Biosciences/GSK; DNA polymerase θ inhibitor - IDEAYA Biosciences; GSK-101; GSK-4524101; IDE-705; Pol theta helicase inhibitor; POLQ inhibitor - IDEAYA Biosciences

Latest Information Update: 11 Feb 2026

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At a glance

  • Originator IDEAYA Biosciences
  • Class Antineoplastics; Small molecules
  • Mechanism of Action DNA polymerase theta inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase I/II Solid tumours

Most Recent Events

  • 04 Dec 2025 GSK terminates its Collaboration, option and license agreement with IDEAYA Biosciences
  • 29 Nov 2023 Phase-I/II clinical trials in Solid tumours (Late-stage disease, Metastatic disease, Monotherapy, Second-line therapy or greater) in USA (unspecified route) (NCT06077877)
  • 24 Oct 2023 Phase-I/II clinical trials in Solid tumours (Late-stage disease, Metastatic disease, Combination therapy, Second-line therapy or greater) in Canada (PO) (NCT06077877)

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