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Paromomycin topical - Appili Therapeutics

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Drug Profile

Paromomycin topical - Appili Therapeutics

Alternative Names: ATI-1801; WR-279-396

Latest Information Update: 18 Feb 2026

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At a glance

  • Originator Department of defence; US Army Medical Research and Development Command
  • Developer Department of defence
  • Class Aminoglycosides; Anthelmintics; Antibacterials; Antiprotozoals; Oligosaccharides; Small molecules
  • Mechanism of Action Protein 30S ribosomal subunit inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Cutaneous leishmaniasis
  • New Molecular Entity No
  • Available For Licensing Yes

Highest Development Phases

  • Phase III Cutaneous leishmaniasis

Most Recent Events

  • 13 Feb 2026 ATI-1801 expects priority review voucher for Cutaneous leishmaniasis in USA in the fourth quarter of 2029
  • 14 Aug 2025 Appili Therapeutics completes the type B meeting with the US FDA
  • 01 Nov 2024 Appili Therapeutics received positive feedback from the US FDA regarding the development strategy for Paromomycin topical

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