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Nivegacetor - Roche

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Drug Profile

Nivegacetor - Roche

Alternative Names: RG-6289

Latest Information Update: 03 Dec 2025

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At a glance

  • Originator Roche
  • Class Antidementias; Azabicyclo compounds; Bridged bicyclo compounds; Ethers; Fluorobenzenes; Methyl ethers; Pyridazines; Pyrrolidines; Triazoles
  • Mechanism of Action Amyloid precursor protein secretase modulators
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Alzheimer's disease

Most Recent Events

  • 03 Dec 2025 Efficacy data from a phase II trial in Alzheimer's disease presented at the Alzheimer's Association International Conference 2025 (AAIC-2025)
  • 13 Aug 2025 Chemical structure information added.
  • 14 Nov 2024 Banner Alzheimers Institute and Neurosciences Group at the University of Antioquia (GNA) in Medellin plans a clinical trial for Alzheimer's-disease (Monotherapy, Prevention, In adults), in fall 2025 (IV) (NCT06996730)

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