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I 022

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Drug Profile

I 022

Alternative Names: I-022; SPH-4336

Latest Information Update: 16 Jul 2024

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At a glance

  • Originator Shanghai Pharmaceutical Group
  • Class Antineoplastics; Small molecules
  • Mechanism of Action Cyclin-dependent kinase 4 inhibitors; Cyclin-dependent kinase 6 inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II/III Breast cancer; HER2 negative breast cancer
  • Phase II Liposarcoma
  • Phase I/II Solid tumours

Most Recent Events

  • 31 May 2024 Efficacy, pharmacokinetics, and adverse events data from a phase I trial in Solid tumours presented at the 60th Annual Meeting of the American Society of Clinical Oncology (ASCO-2024)
  • 26 Oct 2023 Shanghai Pharmaceuticals completes a phase-I trial in Solid tumours (Late-stage disease, In adults, In the elderly) in China (PO, Tablet) (ChiCTR1800019622) (NCT05905614)
  • 17 Oct 2023 Phase-I/II clinical trials in Solid tumours (Late-stage disease, Combination therapy) in China (PO) (NCT05944224)

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