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Claseprubart - Dianthus Therapeutics

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Drug Profile

Claseprubart - Dianthus Therapeutics

Alternative Names: DNTH 103

Latest Information Update: 24 Apr 2026

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At a glance

  • Originator Dianthus Therapeutics
  • Class Antianaemics; Monoclonal antibodies
  • Mechanism of Action Complement C1s inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase III Chronic inflammatory demyelinating polyradiculoneuropathy
  • Phase II Multifocal motor neuropathy; Myasthenia gravis

Most Recent Events

  • 30 Mar 2026 Dianthus Therapeutics completes end of phase II meeting with US FDA for myasthenia gravis
  • 09 Mar 2026 Efficacy and adverse events data from the phase III CAPTIVATE trial in Chronic inflammatory demyelinating polyradiculoneuropathy released by Dianthus Therapeutics
  • 06 Oct 2025 Phase-II clinical trials in Multifocal motor neuropathy (Treatment-experienced) in United Kingdom, Serbia, Spain, Netherlands, Serbia, Macedonia, Italy, France (SC) (NCT06537999)

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