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JMKX 000623

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Drug Profile

JMKX 000623

Alternative Names: JMKX-000623; ODM-111

Latest Information Update: 12 Sep 2025

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At a glance

  • Originator Jemincare
  • Developer Jemincare; Orion
  • Class Non-opioid analgesics; Small molecules
  • Mechanism of Action Nav1.8 voltage-gated sodium channel inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Discontinued Neuropathic pain; Pain

Most Recent Events

  • 28 Oct 2024 Orion Corporation terminates phase II trial for Pain in Czech Republic, Denmark, Germany, Spain, Poland due to safety concerns prior to enrollment (CTIS2024-513553-79-00)
  • 24 Oct 2024 Discontinued - Phase-I for Pain (In volunteers) in Netherlands based on the risk-benefit analysis on the results of a longer non-clinical toxicology study (PO)
  • 24 Oct 2024 Discontinued - Phase-II for Neuropathic pain in China based on the risk-benefit analysis on the results of a longer non-clinical toxicology study (PO)

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