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ISM 3412

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Drug Profile

ISM 3412

Alternative Names: ISM-3412

Latest Information Update: 28 Jun 2026

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At a glance

  • Originator InSilico Medicine
  • Class Antineoplastics; Small molecules
  • Mechanism of Action DNA damage stimulants; MAT2A protein inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase I Solid tumours
  • No development reported Cancer

Most Recent Events

  • 28 Jun 2026 No recent reports of development identified for preclinical development in Cancer in USA (PO)
  • 06 Jan 2025 Phase-I clinical trials in Solid tumours (Late-stage disease, Metastatic disease, Inoperable/Unresectable, Second-line therapy or greater) in China (PO) (NCT06414460)
  • 16 May 2024 InSilico Medicine plans a phase I trial for Solid tumours (Late-stage disease, Metastatic disease, Inoperable/Unresectable, Second-line therapy or greater) in March 2025 (PO) (NCT06414460)

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