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TNG 462

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Drug Profile

TNG 462

Alternative Names: TNG-462

Latest Information Update: 23 May 2025

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At a glance

  • Originator Tango Therapeutics
  • Class Antineoplastics; Small molecules
  • Mechanism of Action PRMT5 protein inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Pancreatic cancer; Soft tissue sarcoma
  • New Molecular Entity Yes
  • Available For Licensing Yes

Highest Development Phases

  • Phase I/II Solid tumours
  • Preclinical Cancer

Most Recent Events

  • 12 May 2025 Tango Therapeutics plans a registrational trial for Pancreatic cancer (Monotherapy) in 2026
  • 25 Apr 2025 Pharmacodynamics data from preclinical trial in Solid tumours presented at the 116th Annual Meeting of the American Association for Cancer Research (AACR-2025)
  • 27 Feb 2025 Tango Therapeutics plans phase I/II clinical trial for Adenocarcinoma and Non-small cell lung cancer (Combination therapy, Second-line therapy and greater, metastatic disease, Late-stage disease) in June 2025 (PO) (NCT06922591)

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