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ZX 8177

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Drug Profile

ZX 8177

Alternative Names: ZX-8177

Latest Information Update: 05 Jan 2026

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At a glance

  • Originator Nanjing Zenshine Pharmaceuticals
  • Class Antineoplastics; Small molecules
  • Mechanism of Action Ectonucleotide pyrophosphatase phosphodiesterase 1 inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase I Solid tumours

Most Recent Events

  • 26 Dec 2025 Phase-I clinical trials in Solid tumours (Metastatic disease, Late-stage disease, Recurrent, Inoperable/Unresectable, Second-line therapy or greater) in China (PO) (NCT07310134)
  • 14 Apr 2023 Pharmacodynamics data from a preclinical in Cancer presented at the 114th Annual Meeting of the American Association for Cancer ResearchSession (AACR-2023)
  • 02 Mar 2023 Nanjing Zenshine Pharmaceuticals plans clinical trial in Solid tumours in 2023 (Nanjing Zenshine Pharmaceuticals pipeline, February 2023)

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