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UP 284

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Drug Profile

UP 284

Alternative Names: UP-284

Latest Information Update: 28 Jun 2026

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At a glance

  • Originator Up Therapeutics
  • Developer Johns Hopkins University; Tuskegee University; Up Therapeutics
  • Class Antineoplastics; Small molecules
  • Mechanism of Action ADRM1 protein inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Preclinical Glioblastoma; Ovarian cancer; Prostate cancer; Triple negative breast cancer
  • No development reported Solid tumours
  • Discontinued Multiple myeloma

Most Recent Events

  • 28 Jun 2026 No recent reports of development identified for preclinical development in Solid-tumours in USA
  • 25 Apr 2025 Pharmacodynamics data from preclinical trials in Triple-negative breast cancer presented at the 116th Annual Meeting of the American Association for Cancer Research (AACR-2025)
  • 13 Sep 2023 Discontinued - Preclinical for Multiple myeloma in USA (unspecified route) (UP Therapeutics pipeline, September 2023)

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