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SAR 445877

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Drug Profile

SAR 445877

Alternative Names: anti-PD-1/IL-15 bi-functional antibody; anti-PD-1/IL-15 fusion protein; KD-050; mut-1N-IL-15/38B2; SAR-445877; SAR-877

Latest Information Update: 28 Nov 2025

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At a glance

  • Originator Kadmon Corporation
  • Developer Sanofi
  • Class Antibodies; Antineoplastics; Immunotherapies; Interleukins; Recombinant fusion proteins
  • Mechanism of Action Antibody-dependent cell cytotoxicity; Interleukin 15 replacements; Programmed cell death-1 ligand-1 inhibitors; T lymphocyte stimulants
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Non-small cell lung cancer
  • Phase I/II Colorectal cancer; Solid tumours

Most Recent Events

  • 14 Nov 2025 Phase-II clinical trials in Non-small cell lung cancer (Late-stage disease, Metastatic disease, Second-line therapy or greater) in USA (IV) (NCT07133425)
  • 21 Aug 2025 Sanofi plans a phase II trial for Non-small cell lung cancer(Late-stage disease, Metastatic disease, Second-line therapy or greater) in USA (IV, Infusion) (NCT07133425)
  • 30 May 2025 Efficacy, adverse events and pharmacodynamics data from a phase I/II trial in Solid tumors presented at the 61st Annual Meeting of the American Society of Clinical Oncology (ASCO-2025)

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