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Ofirnoflast - Halia Therapeutics

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Drug Profile

Ofirnoflast - Halia Therapeutics

Alternative Names: HT 6184

Latest Information Update: 12 Dec 2025

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At a glance

  • Originator Halia Therapeutics
  • Class Analgesics; Anti-inflammatories; Antianaemics; Antidementias; Antineoplastics; Eye disorder therapies; Obesity therapies; Small molecules
  • Mechanism of Action NEK7 protein inhibitors; NLRP3 protein inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Myelodysplastic syndromes
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Anaemia; Inflammatory pain; Myelodysplastic syndromes; Obesity
  • Preclinical Acute myeloid leukaemia; Eye disorders
  • Research Alzheimer's disease
  • No development reported Inflammation

Most Recent Events

  • 08 Dec 2025 Efficacy and adverse events data from a phase IIa trial in Myelodysplastic syndrome released by Halia Therapeutics
  • 08 Dec 2025 Halia Therapeutics is finalizing the dataset and preparing to initiate a global phase III pivotal trial in early 2026
  • 23 Oct 2025 Early research in Alzheimer's disease in USA (unspecified route) (Prior to October 2025)

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