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Ofirnoflast - Halia Therapeutics

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Drug Profile

Ofirnoflast - Halia Therapeutics

Alternative Names: HT 6184

Latest Information Update: 10 Mar 2026

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At a glance

  • Originator Halia Therapeutics
  • Class Amides; Amines; Analgesics; Aniline compounds; Anti-inflammatories; Antianaemics; Antidementias; Antineoplastics; Cyclopropanes; Eye disorder therapies; Fluorinated hydrocarbons; Fluorobenzenes; Isoxazoles; Obesity therapies; Pyrimidines; Pyrroles; Small molecules; Urea compounds
  • Mechanism of Action NEK7 protein inhibitors; NLRP3 protein inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Myelodysplastic syndromes
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Inflammatory pain; Myelodysplastic syndromes; Obesity
  • Preclinical Acute myeloid leukaemia; Eye disorders; Haemolytic anaemia
  • Research Alzheimer's disease
  • No development reported Inflammation

Most Recent Events

  • 10 Mar 2026 Chemical structure information added.
  • 23 Jan 2026 Halia Therapeutics withdraws a phase II clinical trial in Obesity (Combination therapy) in United Arab Emirates(PO), due to business decision to move away from this indication with this intervention and low enrollment (NCT07172867)
  • 08 Dec 2025 Efficacy and adverse events data from a phase IIa trial in Myelodysplastic syndrome released by Halia Therapeutics

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