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Ofirnoflast - Halia Therapeutics

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Drug Profile

Ofirnoflast - Halia Therapeutics

Alternative Names: HT 6184

Latest Information Update: 28 Jul 2025

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At a glance

  • Originator Halia Therapeutics
  • Class Analgesics; Anti-inflammatories; Antianaemics; Antineoplastics; Eye disorder therapies; Obesity therapies; Small molecules
  • Mechanism of Action NEK7 protein inhibitors; NLRP3 protein inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Anaemia; Inflammatory pain; Myelodysplastic syndromes
  • Preclinical Acute myeloid leukaemia; Eye disorders; Obesity
  • No development reported Inflammation

Most Recent Events

  • 28 Jul 2025 No recent reports of development identified for phase-I development in Inflammation(In volunteers) in USA (PO, Capsule)
  • 04 Jun 2025 Halia Therapeutics completes enrolment in its phase IIa trial for Myelodysplastic syndromes in USA and India
  • 11 Mar 2025 Halia Therapeutics plans a phase-II trial for Obesity and Type 2 diabetes mellitus (Combination therapy) in September 2025 (PO) (NCT07172867)

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