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Vorinostat - Unravel Biosciences

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Drug Profile

Vorinostat - Unravel Biosciences

Alternative Names: RVL-001

Latest Information Update: 04 Dec 2025

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At a glance

  • Originator Unravel Biosciences
  • Class Antineoplastics; Hydroxamic acids; Small molecules
  • Mechanism of Action Histone deacetylase inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Rett syndrome
  • New Molecular Entity No

Highest Development Phases

  • Phase 0 Pitt-Hopkins syndrome; Rett syndrome

Most Recent Events

  • 02 Dec 2025 The Colombian Health Regulatory Agency (INVIMA). approves clinical trials application for RVL 001 in Rett syndrome and Pitt Hopkins syndrome .
  • 02 Dec 2025 Unravel Biosciences plans a phase I trial for Rett syndrome(In children, In adolescents, In adults) in Colombia (PO, Suspension) (NCT07150013)
  • 02 Sep 2025 Unravel Biosciences plans a phase I trial for Pitt Hopkins Syndrome (In children, In adolescents, In adults) in Colombia (PO, Suspension) (NCT07150026)

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