Drug Profile

Research programme: PLK-1 degradation therapeutics - Uppthera

Latest Information Update: 28 Feb 2026

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At a glance

Originator UPPTHERA
Class Antineoplastics; Small molecules
Mechanism of Action Polo-like kinase 1 degraders; Ubiquitin protein ligase modulators

Orphan Drug Status

Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

No
New Molecular Entity Yes

Highest Development Phases

No development reported Small cell lung cancer

Most Recent Events

28 Feb 2026 No recent reports of development identified for preclinical development in Small-cell-lung-cancer in South Korea
13 Jun 2022 Uppthera has patents pending for PLK-1 degradation therapeutics in multiple countries
13 Jun 2022 Preclinical trials in Small cell lung cancer in South Korea (unspecified)

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