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E 434

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Drug Profile

E 434

Alternative Names: Bifunctional HER2-Targeted Sialidase - Palleon Pharmaceuticals; E-434; HER2-Sialidase; HLX-314

Latest Information Update: 19 Oct 2022

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At a glance

  • Originator Palleon Pharmaceuticals
  • Class Antineoplastics; Enzymes; Immunotherapies; Monoclonal antibodies; Recombinant fusion proteins
  • Mechanism of Action Dimerisation inhibitors; ERBB 2 receptor antagonists; Membrane glycoprotein modulators; Neuraminidase replacements; T lymphocyte stimulants
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Preclinical Cancer

Most Recent Events

  • 14 Oct 2022 Palleon Pharmaceuticals has patent protection for use of antibody sialidase conjugates in USA
  • 28 Jun 2022 Bifunctional HER2-Targeted Sialidase licensed to Henlius Biopharmaceuticals in China, Hong Kong, Macau, and Taiwan
  • 28 Jun 2022 Preclinical trials in Cancer in USA (Parenteral)

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