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HRS 1167

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Drug Profile

HRS 1167

Alternative Names: HRS-1167; M-9466

Latest Information Update: 01 Jul 2025

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At a glance

  • Originator Jiangsu Hengrui Medicine Co.
  • Developer Jiangsu Hengrui Medicine Co.; Merck KGaA
  • Class Antineoplastics; Small molecules
  • Mechanism of Action Poly(ADP-ribose) polymerase-1 inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Solid tumours
  • Phase I/II Fallopian tube cancer; Ovarian cancer; Peritoneal cancer; Prostate cancer

Most Recent Events

  • 17 Jun 2025 EMD Serono withdraws a phase I trial prior to enrolment for Solid tumors (Late-stage disease, Metastatic disease, Combination Therapy) due to strategic reasons (NCT06719973)
  • 25 Apr 2025 Pharmacodynamics data from a pre-clinical study in Cancer presented at the 116th Annual Meeting of the American Association for Cancer Research (AACR-2025)
  • 24 Feb 2025 Merck KGaA suspends phase I DDRiver 511 trial in Solid tumours (Combination therapy, Late-stage disease, Metastatic disease, Second-line therapy or greater) in USA, Spain, South Korea, Japan, Australia (PO), due to sponsor decision (NCT06509906)

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