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INCA 32459

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Drug Profile

INCA 32459

Alternative Names: INCA-32459

Latest Information Update: 07 Oct 2025

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At a glance

  • Originator Merus
  • Developer Incyte Corporation; Merus
  • Class Antineoplastics; Bispecific antibodies; Immunotherapies
  • Mechanism of Action Antibody-dependent cell cytotoxicity; CD223 antigen inhibitors; Programmed cell death 1 receptor antagonists; T lymphocyte stimulants
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase I Solid tumours

Most Recent Events

  • 07 Oct 2025 Phase-I clinical trial in Solid tumours (Inoperable/Unresectable, Late-stage disease, Metastatic disease, Second-line therapy or greater) is underway in Spain, Italy, Belgium, USA (IV) (NCT05577182)
  • 02 Dec 2022 Phase-I clinical trials in Solid tumours (Inoperable/Unresectable, Late-stage disease, Metastatic disease, Second-line therapy or greater) in Spain, Italy, Belgium (IV) (NCT05577182)
  • 02 Dec 2022 Phase-I clinical trials in Solid tumours (Inoperable/Unresectable, Late-stage disease, Metastatic disease, Second-line therapy or greater) in USA (Parenteral)(NCT05577182)

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