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HRS 4642

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Drug Profile

HRS 4642

Alternative Names: HRS-4642

Latest Information Update: 28 Nov 2025

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At a glance

  • Originator Jiangsu Hengrui Medicine Co.
  • Class 2 ring heterocyclic compounds; Antineoplastics; Azabicyclo compounds; Fluorinated hydrocarbons; Heterocyclic compounds with 4 or more rings; Naphthols; Oxazepines; Pyridines; Pyrimidines; Small molecules
  • Mechanism of Action KRAS protein inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes
  • Available For Licensing Yes

Highest Development Phases

  • Phase II Pancreatic cancer
  • Phase I/II Solid tumours

Most Recent Events

  • 18 Nov 2025 Jiangsu Hengrui Medicine Co. plans a phase III trial for Pancreatic Cancer (First-line therapy, Combination therapy, Late-stage disease, Metastatic disease) in China (Parenteral, Injection) in December 2025 (NCT07232875)
  • 15 Nov 2025 Zhejiang University plans a phase-II trial for Pancreatic cancer (Combination therapy, First-line therapy) in China (IV, infusion) (NCT07240766),
  • 02 Sep 2025 Chemical structure information added.

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