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HRS 4642

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Drug Profile

HRS 4642

Alternative Names: HRS-4642

Latest Information Update: 30 Jan 2026

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At a glance

  • Originator Jiangsu Hengrui Medicine Co.
  • Class 2 ring heterocyclic compounds; Antineoplastics; Azabicyclo compounds; Fluorinated hydrocarbons; Heterocyclic compounds with 4 or more rings; Naphthols; Oxazepines; Pyridines; Pyrimidines; Small molecules
  • Mechanism of Action KRAS protein inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes
  • Available For Licensing Yes

Highest Development Phases

  • Phase II Adenocarcinoma; Pancreatic cancer
  • Phase I/II Solid tumours

Most Recent Events

  • 08 Jan 2026 Shanghai Hengrui Pharmaceutical initiates phase-Ib/II clinical trials in Solid tumours (Combination therapy, Late-stage disease, Inoperable/Unresectable, Metastatic disease) in China (Parenteral) (NCT07296341)
  • 22 Dec 2025 Shanghai Hengrui Pharmaceutical plans a phase Ib/II trial for Solid tumours (Combination therapy, Late-stage disease, Metastatic disease, Inoperable/Unresectable) in China in December 2025 (NCT07296341)
  • 18 Nov 2025 Jiangsu Hengrui Medicine Co. plans a phase III trial for Pancreatic Cancer (First-line therapy, Combination therapy, Late-stage disease, Metastatic disease) in China (Parenteral, Injection) in December 2025 (NCT07232875)

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