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AK 130

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Drug Profile

AK 130

Alternative Names: AK-130

Latest Information Update: 18 Aug 2025

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At a glance

  • Originator Akeso Biopharma
  • Class Antineoplastics; Bispecific antibodies; Immunoglobulin Fc fragments; Immunotherapies; Recombinant fusion proteins
  • Mechanism of Action Immunologic cytotoxicity; TIGIT protein inhibitors; Transforming growth factor beta inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase I Solid tumours

Most Recent Events

  • 11 Aug 2025 Akeso plans a phase II trial for Pancreatic cancer (Late-stage disease, Combination therapy, Metastatic disease, Second-line therapy or greater) in China (IV) in August 2025 (NCT07114315)
  • 29 Apr 2025 Akeso plans a phase I/II trial for Biliary cancer (Late-stage disease, Combination therapy, Second-line therapy or greater, Metastatic disease, ) in China (IV) in May 2025 (NCT06938321)
  • 31 Jul 2024 Akeso plans a phase Ib/II trial for Liver cancer (Late-stage disease, Combination therapy, Second-line therapy or greater) in China (IV) in September 2024 (NCT06530251)

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