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AFA 281

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Drug Profile

AFA 281

Alternative Names: AFA-281

Latest Information Update: 07 Oct 2025

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At a glance

  • Originator AfaSci
  • Class Analgesics; Anti-inflammatories
  • Mechanism of Action Ion channel antagonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase I Inflammatory pain; Neuropathic pain

Most Recent Events

  • 07 Oct 2025 AFA 281 is still in phase-I clinical trials in Inflammatory pain (In volunteers) in USA (PO, Capsule) (NCT05547503)
  • 07 Oct 2025 AFA 281 is still in phase-I clinical trials in Neuropathic pain (In volunteers) in USA (PO, Capsule) (NCT05547503)
  • 06 Dec 2024 Afasci plans a phase I trial for Alcohol related disorders (In volunteers) in January 2025 (PO) (NCT06719908)

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