Drug Profile

TLC 6740

Alternative Names: TLC-6740

Latest Information Update: 22 Dec 2025

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At a glance

Originator Gilead Sciences
Developer OrsoBio
Class Antihypercalcaemics; Hepatoprotectants; Obesity therapies
Mechanism of Action Mitochondrial oxidative phosphorylation uncouplers

Orphan Drug Status

Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

No
New Molecular Entity Yes

Highest Development Phases

Phase I/II Diabetes mellitus; Obesity
Phase I Lipodystrophy; Non-alcoholic steatohepatitis

Most Recent Events

16 Dec 2025 Efficacy and adverse events data from a phase Ib/IIa trial in Obesity released by OrsoBio
16 Dec 2025 OrsoBio plans a phase IIb trial for Obesity, in 2026
05 Nov 2025 Pharmacodynamics data from a preclinical studies in Obesity released by OrsoBio

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