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TLC 1235

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Drug Profile

TLC 1235

Alternative Names: Controlled-release mitochondrial protonophore - OrsoBio; TLC-1235

Latest Information Update: 21 Nov 2022

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At a glance

  • Originator Yale University
  • Developer OrsoBio
  • Class Nitrophenols; Small molecules
  • Mechanism of Action Mitochondrial oxidative phosphorylation uncouplers
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Preclinical Lipodystrophy; Metabolic disorders

Most Recent Events

  • 03 Nov 2022 Pharmacodynamics data from preclinical studies in Lipodystrophy released by OrsoBio (OrsoBio website, November 2022)
  • 02 Nov 2022 OrsoBio in-licenses worldwide rights from Yale University to intellectual property of novel mitochondrial protonophores from Yale University
  • 02 Nov 2022 OrsoBio receives SBIR grant from National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) for TLC 1235 in lipodystrophy

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