Drug Profile

UBB 2048

Alternative Names: UBB-2048

Latest Information Update: 04 Aug 2025

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At a glance

Originator UNITY Biotechnology
Class Bispecific antibodies; Eye disorder therapies; Immunoglobulins
Mechanism of Action TIE-2 receptor agonists; Vascular endothelial growth factor A inhibitors; Vascular endothelial growth factor B inhibitors

Orphan Drug Status

Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

No
New Molecular Entity Yes

01 Aug 2025 Discontinued - Phase-II for Retinal disorders in USA (Intravitreous) (UNITY Biotechnology website, August 2025)
01 Mar 2024 Unity Biotechnology files for patent protection with United States Patent and Trademark Office for UBB 2048 in USA
03 Oct 2023 Phase-II clinical trials in Retinal disorders in USA (Intravitreous), prior to October 2023 (UNITY Biotechnology pipeline, October 2023)

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