Drug Profile

PF 07328948

Alternative Names: PF-07328948

Latest Information Update: 07 Apr 2026

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At a glance

Originator Pfizer
Class 2 ring heterocyclic compounds; Anisoles; Carboxylic acids; Fluorobenzenes; Heart failure therapies; Small molecules; Thiophenes
Mechanism of Action (3-methyl-2-oxobutanoate dehydrogenase (lipoamide)) kinase inhibitors

Orphan Drug Status

Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

No
New Molecular Entity Yes

06 Apr 2026 Chemical structure information added.
03 Apr 2026 Pfizer initiates enrolment in a phase I trial in Healthy volunteers in USA (PO) (NCT07508228)
02 Apr 2026 Phase-II clinical trials in Heart failure (Treatment-experienced) in Bulgaria, Canada, China, Czech Republic, France, Hungary, Japan, Poland, Spain, Spain, United Kingdom (PO) (NCT06991257)

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